Patricia Goldman-Rakic

Patricia Goldman-Rakic

Induction Category:
Science & Health

Born: 1937

Died: 2003

Inducted: 2008

Town: New Haven

When Patricia Goldman-Rakic was tragically killed in 2003, Yale University President Richard Levin described her as “one of the most distinguished neuroscientists of her time.” As one of the first female tenured professors of neuroscience both at Yale and at the National Institute of Mental Health, Goldman-Rakic’s pioneering multi-disciplinary research in working memory and the brain’s prefrontal cortex was groundbreaking and led scientists to deeper knowledge of the brain than ever thought possible.

The daughter of Irvin Schoer, son of Latvian immigrants, and Jenine Pearl, a Russian immigrant, Patricia Schoer was born in Salem, Mass., in 1937. Patricia, her twin sister Ruth, and older sister Linda grew up in Peabody, Mass., where the family moved in the late 1930s. She attended Peabody High School and then Vassar College, where she studied experimental psychology. Schoer graduated from Vassar in 1959 with a B.A. in neurobiology. She went on to UCLA where she earned a Ph.D. in developmental psychology in 1963. Her dissertation research focused on the links between stress and cognitive development in rats and marked the beginning of her interest in the connections between brain development and behavior.

Upon completion of her graduate studies, she began her research at the National Institute of Mental Health, where she worked from 1965 to 1979, eventually becoming its Chief of Developmental Neurobiology. During her time at the NIMH she developed a first of its kind biological map of the brain’s frontal lobe. Until her groundbreaking research, scientists believed that the prefrontal cortex was inaccessible and unable to be studied with conventional scientific methods. She discovered that the prefrontal cortex is much more than a confused mass of firing nerve cells and that it is instead made up of highly specialized nerve cells arranged in columns. Her findings were pivotal to scientists’ understanding of how the brain operates and led to improved understanding of schizophrenia, among other mental illnesses. As NIMH clinical brain disorders head Daniel Weinberger noted, “Her discoveries about the prefrontal cortex reverberated throughout the world of schizophrenia research. She single-handedly elevated it from phenomenology and speculation, to an understanding of basic mechanisms of disease.”

During her time at the NIMH, she spent a year at the Massachusetts Institute of Technology investigating techniques that would expand her own lab’s research capabilities. It was during this year at MIT that she met Pasko Rakic, whom she married in 1979. The couple moved to New Haven, Conn., where he became head of the newly formed Section of Neurobiology at Yale University. Goldman-Rakic would spend the rest of her career at Yale, continuing her pioneering research and expanding its multi-disciplinary reach. She collaborated with other notable researchers to run detailed studies of neuro-chemical development, and the results helped pave the way for improved understanding and treatment of both schizophrenia and Parkinson’s disease, among others. As part of her research, she discovered that cells in the prefrontal cortex are dedicated to specific memory tasks. This led to her development of a theory of working memory, which she also applied to studies of memory loss, schizophrenia, Alzheimer’s disease, and other illnesses. Her work led to new ways of thinking about brain disorders and development.

In addition to her research, Goldman-Rakic was a prolific writer, publishing more than 300 scholarly articles and co-editing three books. With her husband, she founded and co-edited the journal Cerebral Cortex. She was the recipient of numerous awards including the Alden Spencer Award from Columbia University, the Fyssen Prize in Neuroscience, the Lieber Prize from the Brain & Behavior Research Foundation and Gerard Prize from the Society for Neuroscience. She was inducted into the National Academy of Sciences, the National Academy of Arts and Sciences, the Institute of Medicine, and the Vassar College Women in Science Hall of Fame. Goldman-Rakic also received honorary doctorates from the University of Utrecht in the Netherlands and the University of St. Andrews in Scotland. In honor of her immense contributions to the field of neuroscience, several awards are now given in her name.

Though she once told a friend she was unsure if she would be able to “make it in a man’s world,” Goldman-Rakic more than proved that she could. Her pioneering research opened up the field of neuroscience and provided invaluable insight into the functioning of the human brain. Because of her work, innumerable lives have been changed as scientists have been better able to understand brain disorders, from schizophrenia to attention-deficit-hyperactivity disorder, to Alzheimer’s disease.

Patricia Goldman-Rakic died on July 31, 2003, three days after being struck by a car as she crossed a busy street near her New Haven home. Her loss was mourned by the scientific community at large, but her pioneering work lives on in the continued research of new generations of scientists.

During This Time
1966 - Today: Struggle for Justice

Feminism in the late 1960s was aided by President Kennedy, who formed the President’s Commission on the Status of Women in 1961, and his successor, President Johnson, who backed passage of Title VII of the Civil Rights Act of 1964 prohibiting discrimination based on race, sex, national origin, or religion. Difficulties in implementing the law through the Equal Employment Opportunity Commission (EEOC) led a group of women in 1966 to create the National Organization for Women (NOW), demanding “action to bring American women into full participation in the mainstream of American society now.”

A younger group called for a more radical approach to social change than simply considering what was possible to achieve politically. “Women’s liberation” demanded freedom without limitation. Some took part in consciousness-raising groups, others demonstrated against the Miss America pageant, and many discussed their expectations of mutual enjoyment of sex. They established rape crisis centers, domestic shelters, and women’s studies programs. Title IX of the federal Education Amendments Act also increased pressure on universities to hire more women faculty and expand the number of female college athletes. Activist protest among gays and lesbians, such as the Stonewall Riot, symbolized this group’s potential to resist oppression.

Under pressure, many states repealed legislation prohibiting abortion. In 1973, the Supreme Court legalized its availability to women in Roe v. Wade. Also in 1973, the Senate and the House of Representatives passed the ERA, and states began its ratification.

Yet, dissension arose in the ranks of the movement, as it had earlier after passage of the 19th amendment. Feminists disagreed as to whether pornography should be banned or protected as a form of free speech, and whether lesbian identities should be kept secret or disclosed. Black women were more concerned with poverty and welfare in their communities than with personal career advancement; for them, sterilization abuse was more important than abortion, and they were deeply insulted by attacks on the African American family as matriarchal and dysfunctional.

A backlash was growing in the 1970s, along with a New Right in politics. The ERA was defeated and opposition to abortion increased. Conflicts between pro-life and pro-choice candidates have impacted every presidential campaign since then.

Still, gains have been made in many areas. From 1960 to 2000, increasing numbers of women sought entry to higher education, and bachelor’s degrees awarded to them increased from forty to sixty percent.  Definitions of marriage have changed, as when courts gave full rights and responsibilities and the name of marriage to same-sex civil unions in Connecticut in 2008. The Anita Hill-Clarence Thomas hearings in 1991 highlighted concern about sexual harassment on the job, and the number of sexual harassment cases filed with the EEOC have increased, as have judgments in favor of the women. Finally, in 2009, women crossed the fifty percent threshold and became the majority of the American workforce. Once largely confined to repetitive manual jobs, now they are running organizations that once treated them as second-class citizens.

The Women’s Movement has changed women’s lives, influenced the economy, and made debate about their roles, family life, and sexual conventions central to national politics and American history.

Special thanks to Barbara E. Lacey, Ph.D., Professor Emeritus of History, St. Joseph's College (Hartford, CT) for preparing these historical summaries.